Table 3.
Hazards ratios (HR) and 95% CI of inflammatory markers for obesity-related cancers *.
| Tertiles of Inflammatory Markers
|
|||||
|---|---|---|---|---|---|
| Log-transformed | T1 | T2 | T3 | ptrend | |
|
|
|||||
| CRP (ug/mL), Cases (PY *) | 156 (23,047) | 48 (7,935) | 51 (7,643) | 57 (7,469) | |
| Baseline | |||||
| Model 1 | 1.03 (0.89,1.18) | 1.00 | 1.12 (0.76,1.67) | 1.32 (0.89,1.96) | 0.16 |
| Model 2 | 1.01 (0.88,1.17) | 1.00 | 1.11 (0.75,1.65) | 1.30 (0.87,1.94) | 0.19 |
| Updated | |||||
| Model 1 | 1.08 (0.93,1.24) | 1.00 | 0.86 (0.58,1.27) | 1.26 (0.87,1.82) | 0.10 |
| Model 2 | 1.07 (0.92,1.24) | 1.00 | 0.83 (0.56,1.24) | 1.22 (0.83,1.78) | 0.14 |
| Averaged | |||||
| Model 1 | 1.01 (0.86,1.20) | 1.00 | 0.69 (0.46,1.03) | 1.29 (0.91,1.83) | 0.05 |
| Model 2 | 0.98 (0.82,1.17) | 1.00 | 0.66 (0.44,1.00) | 1.22 (0.85,1.77) | 0.11 |
| IL6 (pg/mL), Cases (PY) | 159 (24,646) | 51 (9,009) | 67 (8,318) | 41 (7,319) | |
| Baseline | |||||
| Model 1 | 0.98 (0.78,1.23) | 1.00 | 1.37 (0.95,1.97) | 0.92 (0.61,1.40) | 0.45 |
| Model 2 | 0.94 (0.74,1.20) | 1.00 | 1.34 (0.92,1.94) | 0.90 (0.58,1.38) | 0.37 |
| Updated | |||||
| Model 1 | 0.94 (0.74,1.19) | 1.00 | 1.15 (0.79,1.66) | 0.92 (0.62,1.36) | 0.37 |
| Model 2 | 0.90 (0.71,1.16) | 1.00 | 1.08 (0.74,1.57) | 0.87 (0.58,1.30) | 0.26 |
| Averaged | |||||
| Model 1 | 0.85 (0.66,1.10) | 1.00 | 1.09 (0.77,1.56) | 0.80 (0.54,1.17) | 0.15 |
| Model 2 | 0.78 (0.59,1.02) | 1.00 | 1.03 (0.72,1.49) | 0.72 (0.48,1.07) | 0.06 |
| TNF-α (pg/mL), Cases (PY) | 155 (24,079) | 59 (8,564) | 54 (8,108) | 42 (7,408) | |
| Baseline | |||||
| Model 1 | 0.99 (0.66,1.48) | 1.00 | 1.00 (0.69,1.45) | 0.87 (0.59,1.31) | 0.51 |
| Model 2 | 0.99 (0.65,1.49) | 1.00 | 0.97 (0.67,1.41) | 0.86 (0.57,1.30) | 0.48 |
*
Obesity-related cancers include cancers of breast, endometrium, pancreas and prostate. *PY: person-years.
Model 1: adjusted for age in years (continuous), race (black/white), gender and site.
Model 2: adjusted for age in years (continuous), race (black/white), gender, site, body mass index (kg/m2), smoking (never, former <20 pack-years, former ≥20 pack-years, current <20 pack-years, current ≥20 pack-years), current diabetes, NSAID use (yes/no), baseline physical activity (0, 0–499.9, 500–999.9, 1,000–1,499.9, 1,500–1,999.9, >2,000 Kcal/week) and alcohol consumption (no consumption in the past year, <1 drink/week, 1–7 drinks/week, >1 drinks/day).