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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cell Mol Bioeng. 2016 Jan 19;9(2):247–251. doi: 10.1007/s12195-016-0430-2

FIGURE 2.

FIGURE 2

Stretching force exerted on the nucleus is mainly absorbed by the lamina. The nuclear lamina acts as a signal conditioner by dampening the input force and protecting the nuclear envelope (NE) from stimulus overload. The remaining stretching force changes lipid packaging in the NE and exposes the hydrophobic membrane core to the nucleoplasm, which allows for novel hydrophobic protein interaction/insertions with the inner nuclear membrane.