Table 3.
COPD-related functional outcomes stratified by the three different classification criteria of ventilatory impairment.
| % Predicted
FEV1
|
FEV1 (L) |
|
FEV1/height2(L/m2) |
|
FEV1 Z-score
|
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 to 29 | 30 to 49 | 50 to 79 | ≥80 | RMSE (SD) | 0 to 0.49 | 0.5 to 0.99 | 1 to 1.99 | ≥2 | RMSE (SD) | Bonferroni adjusted P | 0 to 0.39 | 0.4 to 0.59 | 0.6 to 0.79 | ≥0.8 | RMSE (SD) | Bonferroni adjusted P | ≤−4 | −3.99 to −3.0 | −2.99 to −2 | >−2 | RMSE (SD) | Bonferroni adjusted P | |
| Mean 6-minute walk distance in meters (SD) | 265 (106) | 337 (112) | 396 (110) | 459 (99) | 101.6 (27.4) | 207 (94) | 294 (108) | 370 (108) | 448 (104) | 98.6 (27.4) | 0.36 | 295 (112) | 363 (107) | 414 (105) | 468 (97) | 99.7 (27.4) | 1 | 287 (115) | 335 (115) | 380 (112) | 434 (104) | 104.1 (27.2) | 0.56 |
| Mean St George Respiratory Questionnaire Score (SD) | 56.1 (16.3) | 45.9 (19.1) | 34.4 (21.4) | 20.4 (19.0) | 19.0 (4.9) | 60.3 (18.0) | 50.5 (20.7) | 39.5 (21.8) | 26.4 (20.1) | 19.4 (4.9) | 0.44 | 51.1 (18.0) | 40.4 (20.7) | 31.6 (21.8) | 22.7 (20.1) | 19.2 (4.9) | 1 | 56.3 (16.6) | 45.9 (19.3) | 36.8 (20.4) | 25.0 (20.2) | 18.7 (5.0) | 1 |
| Mean SF-36 Physical Health Component Score (SD) | 32.7 (8.6) | 36.4 (9.5) | 41.8 (10.6) | 48.6 (9.9) | 9.8 (2.8) | 31.5 (9.4) | 34.3 (8.9) | 39.4 (10.4) | 45.8 (10.5) | 9.9 (3.0) | 0.60 | 34.5 (9.1) | 38.9 (10.3) | 43.0 (10.3) | 47.6 (10.5) | 9.8 (3.0) | 1 | 32.4 (8.4) | 36.8 (9.9) | 40.5 (10.2) | 45.9 (10.3) | 9.7 (2.7) | 1 |
| Median MMRC Dyspnea Scale Score (IQR) | 3 (1) | 3 (1) | 2 (3) | 0 (2) | 1.6 (0.4) | 4 (1) | 3 (2) | 2 (2) | 1 (2) | 1.6 (0.4) | 0.51 | 3 (2) | 2 (2) | 1 (3) | 0 (2) | 1.6 (0.4) | 1 | 3 (1) | 3 (1) | 2 (2) | 1 (2) | 1.6 (0.4) | 1 |