Table 1.
Treatment and demographic characteristics of survivors of pediatric acute lymphoblastic leukemia at Texas Children's Hospital
| BMI Class at Follow up |
|||||
|---|---|---|---|---|---|
| Overall (n=406) | Underweight (n=11) | Normal (n=193) | Overweight (n=112) | Obese (n=90) | |
| Subtype, n(%)1 | |||||
| B-cell lineage | 27 (6.8) | 9 (90.0) | 169 (90.9) | 96 (87.3) | 82 (91.1) |
| T-cell lineage | 357 (89.9) | 1 (10.0) | 9 (4.8) | 12 (10.9) | 5 (5.6) |
| Infantile | 13 (3.3) | 0 (0.0) | 8 (4.3) | 2 (1.8) | 3 (3.3) |
| Age at Diagnosis, n(%) | |||||
| 0-5 years | 263 (64.8) | 7 (63.6) | 132 (68.4) | 70 (62.5) | 54 (60.0) |
| 6-10 years | 98 (24.1) | 3 (27.3) | 39 (20.2) | 29 (25.9) | 27 (30.0) |
| 11-18 years | 45 (11.1) | 1 (9.1) | 22 (11.4) | 13 (11.6) | 9 (10.0) |
| Mean, year (sd) | 5.44 (3.71) | 5.58 (2.62) | 5.33 (3.87) | 5.53 (3.85) | 5.55 (3.33) |
| Diagnosis BMI, z-score (sd)2 | 0.21 (1.29) | −1.79 (1.31) | −0.23 (1.13) | 0.56 (1.21) | 1.05 (1.01) |
| Race/Ethnicity, n(%) | |||||
| Non-Hispanic white | 199 (49.0) | 8 (72.7) | 110 (57.0) | 52 (46.4) | 29 (32.2) |
| Hispanic | 157 (38.7) | 1 (9.1) | 60 (31.1) | 53 (47.3) | 43 (47.8) |
| Non-Hispanic black | 24 (5.9) | 0 (0.0) | 9 (4.7) | 3 (2.7) | 12 (13.3) |
| Other | 26 (6.4) | 2 (18.2) | 14 (7.2) | 4 (3.6) | 6 (6.7) |
| Gender, n(%) | |||||
| Female | 186 (45.8) | 7 (63.6) | 96 (49.7) | 39 (34.8) | 44 (48.9) |
| Male | 220 (54.2) | 4 (36.4) | 97 (50.3) | 73 (65.2) | 46 (51.1) |
| CRT, n(%)3 | |||||
| None | 360 (89.1) | 9 (81.8) | 180 (93.7) | 94 (84.7) | 77 (85.6) |
| ≤18 Gy | 27 (6.7) | 2 (18.2) | 8 (4.2) | 12 (10.8) | 5 (5.6) |
| ≥24 Gy | 17 (4.2) | 0 (0.0) | 4 (2.1) | 5 (4.5) | 8 (8.8) |
| Year of diagnosis, n(%) | |||||
| 1972-1994 | 89 (21.9) | 1 (9.1) | 40 (20.7) | 25 (22.3) | 23 (25.6) |
| 1995-2008 | 317 (78.1) | 10 (90.9) | 153 (79.3) | 87 (77.7) | 32 (74.4) |
| Age at follow-up, n(%) | |||||
| ≤ 10 years | 42 (10.3) | 0 (0.0) | 23 (11.9) | 23 (20.5) | 16 (17.8) |
| 11-20 years | 260 (64.0) | 9 (81.8) | 132 (68.4) | 64 (57.1) | 51 (56.7) |
| 21-30 years | 92 (22.7) | 1 (9.1) | 34 (17.6) | 22 (19.6) | 19 (21.1) |
| ≥ 31 years | 12 (3.0) | 1 (9.1) | 4 (2.1) | 3 (2.7) | 4 (4.4) |
| Mean, year (sd) | 16.83 (5.94) | 16.35 (6.05) | 16.86 (5.79) | 16.68 (6.13) | 17.04 (6.08) |
| Time fom diagnosis, year (sd) | 11.39 (5.33) | 10.77 (5.17) | 11.53 (4.93) | 11.14 (5.86) | 11.48 (5.54) |
| Treatment duration, year (sd) | 2.84 (1.33) | 3.06 (1.39) | 2.74 (1.25) | 3.02 (1.54) | 2.83 (1.17) |
BMI, Body Mass Index; SD, Standard Deviation; CRT, Cranial Radiation Therapy
1
Missing subtype information on n=10
2
Restricted to patients with height and weight recorded at diagnosis (n=292)
3
Missing radiation dose information on n=2 radiated participants