Table 3.
Logistic regression1 of overweight/obesity among pediatric acute lymphoblastic leukemia survivors at Texas Children's Hospital
| Year of Diagnosis ≥1995 |
|||
|---|---|---|---|
| Complete Data (n=193 normal weight; 202 overweight/obese) | Model 1 (n=153 normal weight; 154 overweight/obese) | Model 22 (n=137 normal weight; 139 overweight/obese) | |
| aOR (95% CI) | aOR (95% CI) | aOR (95% CI) | |
| Age at Diagnosis, year3 | 1.05 (0.97-1.12) | 1.15 (1.04-1.28) | 1.14 (1.02-1.29) |
| Age at Follow up, year | 0.98 (0.94-1.02) | 0.88 (0.80-0.96) | 0.90 (0.81-1.01) |
| CRT | |||
| None | Ref. | Ref. | Ref. |
| Any | 3.44 (1.53-7.74) | 4.72 (1.32-16.90) | 17.45 (1.14-266.26) |
| Age-by-CRT Interaction | 0.84 (0.71-0.98) | 0.77 (0.61-0.96) | 0.66 (0.45-0.96) |
| Gender | |||
| Male | Ref. | Ref. | Ref. |
| Female | 0.74 (0.49-1.13) | 0.86 (0.54-1.38) | 0.77 (0.45-1.33) |
| Race/Ethnicity | |||
| Non-Hispanic white | Ref. | Ref. | Ref. |
| Hispanic | 2.18 (1.40-3.41) | 1.89 (1.14-3.13) | 2.03 (1.14-3.59) |
| Non-Hispanic black | 2.33 (0.95-5.69) | 2.30 (0.88-5.99) | 1.79 (0.56-5.75) |
| Other | 0.93 (0.38-2.26) | 1.08 (0.39-2.96) | 1.08 (0.30-3.85) |
| Diagnosis BMI, z-score | NA | NA | 2.03 (1.57-2.62) |
aOR Adjusted Odds Ratio; CI, Confidence Interval; CRT, Cranial Radiation Therapy; BMI, Body Mass Index
1
Adjusted for age at follow up (continuous) and other variables included in table, relative to normal weight, underweight individuals excluded (n=11)
2
Model 2 restricted to patients with height and weight recorded at diagnosis (n=292)
3
Age at diagnosis centered at 7 years