Table 3.
Development of T2 values and WORMS scores over 6 years
| Follow up | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | 24 months | 48 months | 72 months | ||||||
| mean | 95% CI | mean | 95% CI | mean | 95% CI | mean | 95% CI | p | |
| African Americans | |||||||||
| Average T2 ms | 32.07 | 31.7–32.4 | 33.49 | 33.2–33.8 | 34.16 | 33.8–34.5 | 34.08 | 33.7–34.5 | <0.0001 |
| WORMS sum | 7.79 | 6.47–9.12 | 8.66 | 6.91–10.39 | 12.15 | 10.48–13.82 | 13.84 | 11.88–15.79 | <0.0001 |
| WORMS Cartilage sum | 3.61 | 2.97–4.23 | 4.29 | 3.47–5.11 | 5.88 | 5.09–6.67 | 6.79 | 5.87–7.71 | <0.0001 |
| WORMS BMEP sum | 1.81 | 1.37–2.24 | 2.17 | 1.60–2.74 | 2.83 | 0.28–3.38 | 3.09 | 2.44–3.73 | 0.003 |
| Meniscus sum | 0.9 | 0.54–1.26 | 0.66 | 0.18–1.13 | 1.39 | 0.94–1.85 | 1.54 | 1.01–2.08 | 0.033 |
| Medial meniscus | 0.34 | 0.16–0.52 | 0.26 | 0.02–0.49 | 0.49 | 0.27–0.71 | 0.63 | 0.37–0.89 | 0.148 |
| Lateral meniscus | 0.56 | 0.25–0.87 | 0.4 | −0.01–0.8 | 0.9 | 0.52–1.29 | 0.91 | 0.46–1.37 | 0.191 |
| Ligament sum | 0.22 | 0.10–0.34 | 0.12 | −0.02–0.26 | 0.16 | 0.02–0.30 | 0.04 | −0.04–0.13 | 0.396 |
| Cyst sum | 0.63 | 0.31–0.94 | 0.57 | 0.15–0.98 | 0.95 | 0.56–1.35 | 1.35 | 0.88–1.81 | 0.043 |
| Effusion | 0.12 | 0.04–0.19 | 0.05 | −0.04–0.14 | 0.11 | 0.02–0.19 | 0.13 | 0.03–0.23 | 0.629 |
| Baker cyst | 0.65 | 0.42–0.87 | 0.79 | 0.53–1.06 | 0.83 | 0.57–1.08 | 0.89 | 0.59–1.18 | 0.563 |
| Caucasian Americans | |||||||||
| Average T2 ms | 32.85 | 32.5–33.2 | 33.97 | 33.8–34.4 | 34.43 | 34.2–34.9 | 34.23 | 33.9–34.7 | <0.0001 |
| WORMS sum | 7.57 | 6.58–8.56 | 8.91 | 7.44–10.38 | 10.93 | 8.98–12.89 | 12.38 | 9.57–15.19 | 0.0003 |
| WORMS Cartilage sum | 3.62 | 2.96–4.28 | 4.54 | 3.69–5.38 | 5.75 | 4.90–6.60 | 6.44 | 5.45–7.43 | <0.0001 |
| WORMS BMEP sum | 1.35 | 0.99–1.71 | 1.71 | 1.25–2.16 | 2.02 | 1.56–2.48 | 2.11 | 1.58–2.65 | 0.052 |
| Meniscus sum | 1.36 | 0.89–1.83 | 1.42 | 0.82–2.02 | 1.85 | 1.25–2.45 | 2.02 | 1.32–2.72 | 0.328 |
| Medial meniscus | 0.61 | 0.38–0.84 | 0.55 | 0.26–0.84 | 0.74 | 0.44–1.03 | 0.87 | 0.52–1.21 | 0.494 |
| Lateral meniscus | 0.75 | 0.33–1.16 | 0.87 | 0.34–1.40 | 1.11 | 0.58–1.65 | 1.15 | 0.54–1.78 | 0.626 |
| Ligament sum | 0.28 | 0.17–0.39 | 0.08 | −0.07–0.23 | 0.15 | 0.00–0.29 | 0.09 | −0.08–0.26 | 0.117 |
| Cyst sum | 0.29 | 0.05–0.53 | 0.42 | 0.11–0.72 | 0.48 | 0.17–0.78 | 0.82 | 0.46–1.18 | 0.119 |
| Effusion | 0.06 | 0.03–0.09 | 0.00 | −0.04–0.04 | 0.00 | −0.04–0.04 | 0.00 | −0.05–0.05 | 0.042 |
| Baker cyst | 0.66 | 0.43–0.88 | 0.77 | 0.48–1.05 | 0.69 | 0.41–0.97 | 0.89 | 0.56–1.21 | 0.68 |
Significance of differences over all time points was tested with ANOVA, level of confidence p < 0.05. Part of baseline data were reported in Yu et al. 20157