Figure 3.
Temporal changes of (a) oxygen concentration ([3O2]) and (b) reactive singlet oxygen concentration ([1O2]rx) during Photofrin-mediated PDT. Initial oxygen concentration ([3O2]0) has been changed from 3.25 to 26 μM. The in-air fluence rate and total fluence are considered to be 80 mW/cm2 and 150 J/cm2, respectively. The solid and dashed lines are the calculations with and without considering the blood flow changes, respectively; the symbols are the measured [3O2] post PDT for different [3O2]0, reported by Ref.18
