Table 2. Diagnostic accuracy of ALT/AST ratio alone at various ALT/AST ratio cut-points compared to the presence of hepatic steatosis on computed tomography scan in the Framingham Heart Study.
ALT/AST ratio cut-points | Prevalence steatosis (%)* | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
---|---|---|---|---|---|
0.9 | 74 | 90 | 33 | 33 | 90 |
1.05 | 56 | 80 | 51 | 37 | 87 |
1.18 | 44 | 70 | 65 | 42 | 85 |
1.22 | 39 | 66 | 70 | 44 | 85 |
1.33 | 29 | 55 | 80 | 50 | 83 |
1.5 | 17 | 34 | 91 | 54 | 79 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; PPV, positive predictive value; NPV, negative predictive value
Prevalence of hepatic steatosis in the Framingham Heart Study sample based on ALT/AST ratio cut-point.