Table 3.
Laboratory values by gender and phenotype in CFLD patients
| Description | All n =561 | Males n =353 | Females n =208 | p value | No known varices n =154 | Varices present n =384 | p value | No liver transplant n =470 | Liver transplant n =91 | p value |
|---|---|---|---|---|---|---|---|---|---|---|
| Male gender, n (%) | 353 (63) | 0.0006 | 98 (64) | 241 (63) | 0.94 | 294 (63) | 59 (65) | 0.85 | ||
| Alanine aminotransferase (ALT), IU/L | n =532 | n =334 | n =198 | n =150 | n =365 | n =454 | n=78 | |||
| Median (25th, 75th) | 41 (28, 67) | 44 (28, 71) | 38 (26, 36) | 0.01a | 46 (31, 68) | 40 (27, 66) | 0.09 | 42 (28, 68) | 39 (27, 59) | 0.56 |
| Gamma-glutamyl transferase (GGT), IU/L | n =456 | n =295 | n =161 | n =128 | n =316 | n =390 | n =66 | |||
| Median (25th, 75th) | 60 (30, 123) | 66 (33, 127) | 51 (25, 113) | 0.04 | 63 (30, 106) | 57 (30, 126) | 0.96 | 61 (31, 123) | 52 (25, 134) | 0.83 |
| Total bilirubin, mg/dL | n =474 | n =292 | n =182 | n =119 | n =341 | n =394 | n =80 | |||
| Median (25th, 75th) | 0.8 (0.5, 1.3) | 0.8 (0.5, 1.3) | 0.8 (0.5, 1.4) | 0.74 | 0.7 (0.4, 1.0) | 0.9 (0.5, 1.5) | 0.0001 | 0.8 (0.5, 1.2) | 1.0 (0.7, 1.6) | 0.001 |
| Direct bilirubin, mg/dL | n =231 | n =143 | n =88 | n =53 | n =1 70 | n =194 | n =37 | |||
| Median (25th, 75th) | 0.3 (0.2, 0.6) | 0.3 (0.2, 0.6) | 0.3 (0.2, 0.6) | 0.66 | 0.2 (0.1, 0.4) | 0.4 (0.2, 0.7) | 0.0001 | 0.3 (0.2, 0.5) | 0.4 (0.3, 0.8) | 0.01 |
| Albumin, g/dL | n =493 | n =306 | n =187 | n =138 | n =342 | n =418 | n =75 | |||
| Median (25th, 75th) | 3.6 (3.2, 4.0) | 3.7 (3.3, 4.0) | 3.5 (3.0, 3.9) | 0.0007 | 3.8 (3.3, 4.1) | 3.5 (3.1, 3.9) | 0.001 | 3.7 (3.2, 4.0) | 3.3 (2.9, 3.8) | 0.0002 |
| International normalized ratio (INR) | n =360 | n =223 | n =137 | n =100 | n =249 | n =310 | n =50 | |||
| Median (25th, 75th) | 1.2 (1.1, 1.4) | 1.3 (1.1, 1.4) | 1.2 (1.1, 1.3) | 0.03 | 1.2 (1.1, 1.3) | 1.3 (1.1, 1.4) | <0.0001 | 1.2 (1.1, 1.4) | 1.4 (1.2, 1.7) | <0.0001 |
| Platelet count (×109/L) | n =464 | n =290 | n =174 | n =134 | n =313 | n =402 | n =62 | |||
| Median (25th, 75th) | 103 (65, 166) | 101 (62, 160) | 111 (69, 172) | 0.34 | 145 (87, 198) | 88 (56, 142) | <0.0001 | 113 (70, 171) | 78 (54, 99) | <0.0001 |
| < 150, n (%) | 324 (70) | 208 (72) | 116 (67) | 0.65 | 74 (55) | 243 (78) | 0.048 | 269 (67) | 55 (89) | 0.19 |
| < 75, n (%) | 140 (30) | 91 (31) | 49 (28) | 0.62 | 21 (16) | 117 (37) | 0.0006 | 113 (28) | 27 (44) | 0.10 |
p values (<0.05 shown in bold) generated using Fisher's exact test (for categorical data) or Wilcoxon rank sum (for medians).
Data presented as median with 25th and 75th percentiles or frequency with percent.
a
Apparent difference between genders is clinically non-significant due to different ULN in ALT for males and females.