Table 4.
Liver-related biomarkers/ratios by gender, age, and phenotype in CFLD patients
| Description | n | APRia | FIB-4b | Agec, years | Platelets, ×109/L | AST, IU/L | ALT, IU/L | |
|---|---|---|---|---|---|---|---|---|
| All CFLD Patients | All | 497 | 1.15 (0.66, 2.05) | 1.16 (0.61, 2.04) | 16.1 (12.3, 21.2) | 101 (63, 161) | 45 (31, 67) | 41 (28, 68) |
| Male | 310 | 1.23 (0.68, 2.18) | 1.25 (0.63, 2.22) | 16.0 (12.1, 20.5) | 98 (61, 157) | 47 (32, 69) | 44 (30, 72) | |
| Female | 187 | 1.05 (0.63, 1.73) | 1.06 (0.61, 1.92) | 16.9 (12.4, 21.8) | 110 (67, 166) | 41 (30, 62) | 38 (26, 56) | |
| p valued | 0.038 | 0.308 | 0.155 | 0.295 | 0.029 | 0.011e | ||
| Age < 18 years | All | 302 | 1.25 (0.74, 2.10) | 1.01 (0.49, 1.74) | 13.1 (10.5, 15.6) | 103 (69, 160) | 48 (37, 73) | 43 (31, 71) |
| Male | 197 | 1.34 (0.74, 2.23) | 1.08 (0.54, 1.78) | 13.2 (10.4, 15.7) | 103 (65, 153) | 49 (38, 78) | 46 (30, 73) | |
| Female | 105 | 1.16 (0.75, 1.77) | 0.80 (0.43, 1.56) | 12.9 (10.8, 15.6) | 102 (72, 174) | 47 (36, 66) | 41 (32, 64) | |
| p valued | 0.102 | 0.108 | 0.774 | 0.416 | 0.169 | 0.353 | ||
| Age ≥ 18 years | All | 195 | 0.99 (0.58,1.99) | 1.56, (0.83, 2.78) | 22.5 (19.9, 26.0) | 100 (58, 164) | 36 (27, 57) | 39 (24. 62) |
| Male | 113 | 1.05 (0.58, 2.04) | 1.62 (0.79, 2.91) | 22.4 (19.6, 25.8) | 90 (56, 167) | 39 (27, 58) | 43 (29, 68) | |
| Female | 82 | 0.88 (0.55, 1.56) | 1.40 (0.85, 2.37) | 22.7 (20.2, 26.3) | 113 (63, 160) | 34 (26, 53) | 36 (21, 51) | |
| p valued | 0.329 | 0.658 | 0.489 | 0.523 | 0.213 | 0.010e | ||
| p value by agef | All | 0.004 | <0.0001 | not applicable | 0.409 | <0.0001 | 0.007e | |
| Male | 0.031 | 0.0001 | not applicable | 0.411 | <0.0001 | 0.264 | ||
| Female | 0.078 | <0.0001 | not applicable | 0.632 | 0.0002 | 0.006e | ||
| Known varices | No varices | 139 | 0.90 (0.48, 1.48) | 0.70 (0.41, 1.26) | 15.3 (11.2, 19.3) | 145 (87, 198) | 45 (31, 65) | 46 (31, 70) |
| Varices | 335 | 1.27 (0.72, 2.29) | 1.47 (0.81, 2.47) | 17.6 (13.7, 22.2) | 88 (56, 142) | 44 (31, 65) | 41 (27, 66) | |
| p valued | <0.0001 | <0.0001 | 0.001 | <0.0001 | 0.691 | 0.100 | ||
| Liver transplant | No transplant | 422 | 1.06 (0.62, 1.99) | 1.05 (0.57, 1.87) | 17.0 (12.7, 21.4) | 113 (70, 171) | 45 (31, 65) | 42 (29, 69) |
| Transplant | 68 | 1.59 (1.11, 2.69) | 1.96 (1.18, 3.25) | 13.3 (10.2, 17.1) | 78 (54, 99) | 45 (32, 72) | 38 (27, 59) | |
| p valued | 0.0001 | <0.0001 | 0.0005 | <0.0001 | 0.549 | 0.349 | ||
p values (<0.05 shown in bold) generated using Wilcoxon rank sum test (for medians).
Data presented as median (25th and 75th percentiles).
a
APRi = (AST [IU/L]/ULN AST*100)/platelet count [109/L]. ULN for AST was 40 IU/L.
b
FIB-4 = (Age [years] * AST [IU/L])/(platelet count [109L] * square root ALT [IU/L]).
c
Age, in years = age at blood test.
d
p value comparing males vs. females
e
The apparent difference between genders is clinically non-significant due to different upper limit of number (ULN) in ALT for males and females.
f
p value by age comparing patients with blood tests performed < 18 vs. ≥ 18 years of age.