Table 6.

Ingenuity Pathway Analysis Canonical pathways represented by proteins that are differentially expressed between IPS and infectious lung injury.

Ingenuity Canonical Pathways	−log(B-H p-value)	Ratio$	z-score	Molecules
LXR/RXR Activation	1.64E01	1.32E-01	1.500	KNG1, APOE, TTR, HPX, APOA4, C3, APOH, A1BG, PON1, LYZ, ITIH4, S100A8, GC, CLU, APOD, AGT
FXR/RXR Activation	1.33E01	1.11E-01	NaN	KNG1, APOE, TTR, HPX, APOA4, C3, APOH, A1BG, PON1, ITIH4, GC, CLU, APOD, AGT
Acute Phase Response Signaling	9.03E00	7.1E-02	−0.378	PLG, TTR, HPX, ITIH3, C3, APOH, ITIH4, SERPINA3, HRG, F2, AGT, C5
Atherosclerosis Signaling	5.38E00	6.45E-02	NaN	APOE, PON1, LYZ, APOA4, S100A8, CLU, PRDX6, APOD
Complement System	4.63E00	1.35E-01	0.447	CD55, C3, CFI, CFH, C5
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	4.32E00	4.44E-02	0.000	APOE, PON1, LYZ, APOA4, S100A8, CLU, SIRPA, APOD
Clathrin-mediated Endocytosis Signaling	4.3E00	4.32E-02	NaN	APOE, PON1, LYZ, APOA4, S100A8, F2, CLU, APOD
IL-12 Signaling and Production in Macrophages	4.27E00	5.26E-02	NaN	APOE, PON1, LYZ, APOA4, S100A8, CLU, APOD
Coagulation System	3.44E00	1.14E-01	0.000	KNG1, PLG, PROS1, F2
Neuroprotective Role of THOP1 in Alzheimer's Disease	3.25E00	1E-01	NaN	KNG1, PLG, SERPINA3, AGT
Intrinsic Prothrombin Activation Pathway	2.32E00	1.03E-01	NaN	KNG1, PROS1, F2
Granulocyte Adhesion and Diapedesis	1.73E00	2.82E-02	NaN	SELL, ICAM2, EZR, MSN, C5
Agranulocyte Adhesion and Diapedesis	1.64E00	2.65E-02	NaN	SELL, ICAM2, EZR, MSN, C5
γ-glutamyl Cycle	1.6E00	1.33E-01	NaN	GSS, ANPEP
Phagosome maturation	1.6E00	3.33E-02	NaN	CALR, LAMP2, PRDX1, PRDX6
Extrinsic Prothrombin Activation Pathway	1.6E00	1.25E-01	NaN	PROS1, F2
Glutathione Redox Reactions I	1.47E00	1.05E-01	NaN	GPX3, PRDX6

^$Ratio is the number of genes in a given pathway divided by the total number genes in that pathway in a reference gene set