TABLE II.
Late Toxicities After Head and Neck Intensity Modulated Radiation Therapy for Pediatric Rhabdomyosarcoma
| Late Toxicity | No. of Evaluable Patients | Any Grade No. (%) | Grade 1 No. | Grade 2 No. | Grade 3 No. | Grade 4 No. |
|---|---|---|---|---|---|---|
| Facial disfigurement | 30 | 23 (76.7) | - | - | - | - |
| Growth hormone deficiency | 30 | 11 (36.7) | 1 | 9 | 0 | 0 |
| Cataract | 29 | 10 (34.5) | 7 | 2 | 0 | 0 |
| Dental problems | 30 | 10 (33.3) | - | - | - | - |
| Psychological/behavioral problems | 30 | 9 (33.0) | 6 | 3 | 0 | 0 |
| Central hypothyroidism | 29 | 7 (24.1) | 0 | 6 | 0 | 0 |
| Chronic sinusitis | 30 | 7 (23.3) | 3 | 3 | 1 | 0 |
| Chronic otitis | 30 | 6 (20.0) | 1 | 2 | 3 | 0 |
| Hearing loss | 30 | 6 (20.0) | 0 | 3 | 2 | 0 |
| Visual disturbance | 30 | 6 (20.0) | 3 | 1 | 2 | 0 |
| Trismus | 30 | 4 (13.3) | 4 | 0 | 0 | 0 |
| Epistaxis | 30 | 4 (13.3) | 4 | 0 | 0 | 0 |
| Cognitive deficits | 30 | 4 (13.3) | 3 | 0 | 0 | 0 |
| ACTH deficiency | 30 | 4 (13.3) | 0 | 3 | 0 | 0 |
| LH/FSH deficiency | 30 | 4 (13.3) | 1 | 2 | 0 | 0 |
| Primary hypothyroidism | 29 | 3 (10.3) | 0 | 3 | 0 | 0 |
| Nasal congestion | 30 | 3 (10.0) | 3 | 0 | 0 | 0 |
| Ptosis | 30 | 2 (6.7) | 0 | 0 | 2 | 0 |
| Voice changes | 30 | 2 (6.7) | 2 | 0 | 0 | 0 |
| Secondary malignancy | 30 | 2 (6.7) | 0 | 0 | 0 | 2 |
| Thyroid nodule | 28 | 1 (3.6) | 1 | 0 | 0 | 0 |
| Glaucoma | 30 | 1 (3.3) | 1 | 0 | 0 | 0 |
| Amblyopia | 30 | 1 (3.3) | 1 | 0 | 0 | 0 |
| Schwannoma | 30 | 1 (3.3) | 1 | 0 | 0 | 0 |