Table 2.
Linear Regression: Association Between Plasma Adiponectin Levels and Neuroimaging and Cognitive Outcomes by Sex
| Model 1 | ||||
|---|---|---|---|---|
| Men | Women | |||
| B (95% CI) | P value | B (95% CI) | P value | |
| Neuroimaging outcomes | ||||
| HVa,* cm3 | −0.489 (−0.884, −0.093) | .016 | −0.544 (−1.09, 0.002) | .051 |
| AD signature thickness, mm | −0.103 (−0.186, −0.020) | .015 | 0.003 (−0.105, 0.111) | .951 |
| Amyloid PET, SUVR | 0.037 (−0.068, 0.143) | .487 | −0.028 (−0.178, 0.122) | .714 |
| FDG PET, SUVR | −0.107 (−0.179, −0.035) | .004 | −0.064 (−0.157, 0.029) | .177 |
| Cognitive outcomes | ||||
| Memory domain, z-score | 0.041 (−0.455, 0.537) | .871 | −0.734 (−1.53, 0.063) | .071 |
| Language domain, z-score | 0.033 (−0.382, 0.448) | .877 | −0.560 (−1.17, 0.053) | .073 |
| Attention domain, z-score | 0.165 (−0.229, 0.559) | .411 | −0.060 (−0.676, 0.556) | .847 |
| Visual-spatial domain, z-score | −0.060 (−0.474, 0.354) | .775 | −0.172 (−0.818, 0.474) | .600 |
| Global cognition, z-score | 0.070 (−0.341, 0.480) | .739 | −0.549 (−1.19, 0.097) | .095 |
| Model 2 | ||||
|---|---|---|---|---|
| Men | Women | |||
| B (95% CI) | P value | B (95% CI) | P value | |
| Neuroimaging outcomes | ||||
| HVa,* cm3 | −0.154 (−0.558, 0.249) | .453 | −0.595 (−1.19, −0.005) | .048 |
| AD signature thickness, mm | −0.067 (−0.153, 0.020) | .131 | −0.023 (−0.134, 0.089) | .689 |
| Amyloid PET, SUVR | −0.040 (−0.151, 0.071) | .476 | 0.009 (−0.148, 0.166) | .909 |
| FDG PET, SUVR | −0.087 (−0.166, −0.008) | .031 | −0.080 (−0.181, 0.021) | .120 |
| Cognitive outcomes | ||||
| Memory domain, z-score | 0.028 (−0.511, 0.566) | .919 | −0.769 (−1.59, 0.051) | .066 |
| Language domain, z-score | 0.014 (−0.438, 0.465) | .952 | −0.777 (−1.42, −0.138) | .017 |
| Attention domain, z-score | 0.137 (−0.284, 0.559) | .522 | −0.421 (−1.07, 0.232) | .205 |
| Visual-spatial domain, z-score | −0.133 (−0.584, 0.318) | .562 | −0.220 (−0.918, 0.479) | .536 |
| Global cognition, z-score | 0.062 (−0.384, 0.509) | .783 | −0.729 (−1.40, −0.053) | .035 |
Model 1 was adjusted for age and education. Men: HVa, n=322; amyloid and FDG, n=324; cortical thickness, n=321; memory, n=322; language, n=316; attention, n=306; visual-spatial, n=308; global, n=301. Women: HVa and cortical thickness, n=203; amyloid and FDG, n=204; memory, n=203; language, n=196; attention, n=197; visual-spatial, n=196; global, n=193. Model 2 was adjusted for age, years of education, waist-to-hip ratio, current diabetes and hypertension, and APOE ε4 status. Men: HVa, n=311; amyloid and FDG, n=313; cortical thickness, n=310; memory, n=312; language, n=306; attention, n=298; visual-spatial, n=300; global, n=293. Women: neuroimaging outcomes, n=199; memory, n=198; language and visual-spatial, n=191; attention, n=192; global, n=188.
HVa adjusted for total intracranial volume.