Fig 7.

Rescue of CD8 development in 4KO thymus by Bcl2l11^−/−thymocytes. (a) Flow cytometric plots and (b) quantitation of CD4^–CD8⁺ TCRβ^hi thymocytes in indicated BM → host chimeras. (c) Fold increase in CD4^-CD8⁺TCRβ^hi thymocytes from mice receiving Bcl2l11^−/− vs. wild-type BM. (n=22 WT→WT,16 Bcl211^−/−→WT,16 WT→4KO, 16 Bcl211^−/−→4KO; male and female, combined from 5 experiments) Numbers on gates indicate percent of total thymocytes. *P<0.05 in b, (One-way ANOVA with Dunnett's multiple comparison post-test). **P=0.0005 in c, (Student's t-test) b and c (mean±SD)