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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Hepatol. 2016 Apr 4;65(2):252–258. doi: 10.1016/j.jhep.2016.03.016

Fig. 4. Sequence-specific modulation of KIR2DL3 binding and NK cell function.

Fig. 4

(A) HLA-C*03:04 expression by 721.221-ICP47-C*03:04 cells pulsed with genotype variants of YLVL. (B) Relative binding of KIR2DL3-Fc to 721.221-ICP47-C*03:04 cells pulsed with genotype variants of YLVL. (C) Relative induction of KIR2DL3 binding in relation to stabilization of HLA-C*03:04 on 721.221-ICP47-C*03:04 cells pulsed with genotype variants of YLVL. (D) Relative frequency of CD107a+ NK cells out of KIR2DL3+ NK cells when co-cultured with 721.221-ICP47-C*03:04 cells pulsed with YLVL and its genotype variants in comparison to GKL. Each bar represents the mean +/− SEM of 5 independent experiments. The grey area is underlying the positive and negative controls.