Table 4. Summary of modulatory activity of selected dietary flavonoid derivatives for P-gp.

KB CH^R 8-5 cells were incubated with 0.5 μg/ml rhodamine 123 for 45 min and 0.5 μM calcein-AM for 10 min at 37 °C under subdued light in the presence and absence of 10 μM of dietary flavonoids. Cells were washed once with DMEM medium and data were recorded in spectroflurometer at 488 nm and 530 nm. The percentage of transport inhibition was derived by taking the level of inhibition obtained with control value equal to 100 %, and the values shown are the average of two independent experiments done in triplicate.

S.No.	Compound	Structure	Tested Concentration (μM)	Rh12 3 % inhibition	Calc ein-AM Efflu x % inhibition
1.	Quercetin		10	88.09	96.41
2.	Rutin		10	85.01	90.07
3.	Theaflavine		10	83.22	88.76
4.	(-)-Epicatechin 3-gallate		10	80.56	83.25
5.	Tamarixetin		10	77.15	78.69
6.	Naringin		10	75.62	70.21
7.	Silibinin		10	71.42	63.75
8.	Myricetin		10	55.79	57.16
9.	Pelargonidin		10	47.16	45.98
10.	Morin		10	40.54	42.81
11.	Apigenin		10	35.01	39.54
12.	Kaempferol		10	25.08	33.78
13.	Hesperidin		10	21.09	29.58
14.	Isorhamnetin		10	19.46	23.05
15.	Isoquercitrin		10	18.35	19.76
16.	Proanthocyanidin		10	15.83	18.52
17.	Fistein		10	13.09	16.76
18.	Tangeritin		10	12.76	14.23
19.	Acacetin		10	12.53	13.89
20.	Luteolin		10	11.46	12.56
21.	Baicalein		10	7.54	11.03
22.	Diosmetin		10	4.32	9.62
23.	Retusin		10	3.06	6.43
24.	Diadzein		10	2.59	3.42