Table 3.
Interaction between time after motor vehicle collision and effect of CRHBP and FKBP5 risk allele on musculoskeletal pain severity.
| Gene/SNPb | Risk allele | Pain Intensity (0–10 numeric rating scale) | |||
|---|---|---|---|---|---|
| 6 weeks | 6 months | 1 year | Interaction p-valuea |
||
| CRHBP H2 |
Present | 3.9 (3.7, 4.2) | 3.3 (3.0, 3.5) | 3.5 (3.2, 3.7) | 0.015 |
| Absent | 3.7 (3.4, 4.0) | 2.8 (2.6, 3.1) | 2.8 (2.6, 3.1) | ||
| FKBP5 rs3800373 |
Present | 4.1 (3.9, 4.4) | 3.4 (3.2, 3.7) | 3.5 (3.2, 3.8) | 0.40 |
| Absent | 3.6 (3.3, 3.9) | 2.9 (2.6, 3.1) | 3.1 (2.8, 3.4) | ||
a
Repeated measures regression model (6 weeks, 6 month, 1 year), dominant genetic model with a gene-week interaction term, adjusted for week, past pain severity, sex, study site
b
CRHBP H2 refers to haplotype 2 of the gene encoding corticotropin-releasing hormone binding protein and FKBP5 is the gene encoding FK506 binding protein 51