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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Pain. 2016 Jan;157(1):273–279. doi: 10.1097/j.pain.0000000000000374

Table 4.

CRHBP × FKBP5 interaction predicting overall pain intensity (0–10 NRS) over time following motor vehicle collision

Time after
motor
vehicle
collision
FKBP5
rs3800373
genotypea
Number of
CRHBP
H2
haplotypes
Mean pain severity
(95% CI)
p-value Gene-gene
interaction
p-value
Six weeks 0 1 or 2 3.8 (3.6, 4.1) 0.844 <0.0001
0 0 3.9 (3.6, 4.2)
1 1 or 2 5.5 (4.6, 6.3) <0.0001
1 0 2.8 (1.8, 3.8)
Six months 0 1 or 2 3.2 (3.0, 3.5) 0.1514 0.111
0 0 3.0 (2.6, 3.2)
1 1 or 2 4.4 (3.4, 5.4) 0.0596
1 0 3.0 (1.8, 4.2)
One year 0 1 or 2 3.6 (3.3, 3.8) 0.0038 0.5774
0 0 3.0 (2.7, 3.3)
1 1 or 2 3.9 (2.8, 4.9) 0.3326
1 0 3.2 (1.9, 4.4)
a

genotype is coded 0=homozygous on major allele or heterozygous, 1= homozygous on minor allele. Gene × gene × time 3 way interaction, p = 0.0031.