Table 4.
CRHBP × FKBP5 interaction predicting overall pain intensity (0–10 NRS) over time following motor vehicle collision
Time after motor vehicle collision |
FKBP5 rs3800373 genotypea |
Number of CRHBP H2 haplotypes |
Mean pain severity (95% CI) |
p-value | Gene-gene interaction p-value |
---|---|---|---|---|---|
Six weeks | 0 | 1 or 2 | 3.8 (3.6, 4.1) | 0.844 | <0.0001 |
0 | 0 | 3.9 (3.6, 4.2) | |||
1 | 1 or 2 | 5.5 (4.6, 6.3) | <0.0001 | ||
1 | 0 | 2.8 (1.8, 3.8) | |||
Six months | 0 | 1 or 2 | 3.2 (3.0, 3.5) | 0.1514 | 0.111 |
0 | 0 | 3.0 (2.6, 3.2) | |||
1 | 1 or 2 | 4.4 (3.4, 5.4) | 0.0596 | ||
1 | 0 | 3.0 (1.8, 4.2) | |||
One year | 0 | 1 or 2 | 3.6 (3.3, 3.8) | 0.0038 | 0.5774 |
0 | 0 | 3.0 (2.7, 3.3) | |||
1 | 1 or 2 | 3.9 (2.8, 4.9) | 0.3326 | ||
1 | 0 | 3.2 (1.9, 4.4) |
genotype is coded 0=homozygous on major allele or heterozygous, 1= homozygous on minor allele. Gene × gene × time 3 way interaction, p = 0.0031.