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Anti-trypanosomal and anti Trypanosoma cruzi tubulin activities of five imido-1, 4-naphthoquinone derivatives. Nifurtimox is included as an anti-trypanosomal activity reference.
| Molecule | Structure | Anti-trypanosome IC50 (μM) | Anti T. cruzi tubulin IC50 (μM) |
|---|---|---|---|
| Nifurtimox |
|
10.67 | N/A |
| IMDNQ1 |
|
2.77 | 6 |
| IMDNQ2 |
|
4.83 | 12 |
| IMDNQ3 |
|
0.70 | 3.2 |
| IMDNQ10 |
|
2.23 | 8 |
| IMDNQ11 |
|
6.10 | >40 |
