Table 2.
Activities and Binding Energies of the validation ligands at the putative site.
| Molecule | Anti-Tubulin IC50 (μM) | Binding Energy in putative site (kcal/mole) |
|---|---|---|
| IMDNQ1 | 6 | 6.23 |
| IMDNQ2 | 12 | 6.21 |
| IMDNQ3 | 3.2 | 7.01 |
| IMDNQ10 | 8 | 6.74 |
| IMDNQ11 | >40 | 6.01 |
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