Table 2.

Risk of CRC associated with family history of CRC

Author, Year	Study population	N	Age	% female	Outcome	Lowest risk reported [family history level]	Highest risk reported) [family history level]
Taylor 201017	Utah Population Database	2 327 327	NR	NR	Incident CRC (SMR)	0.89 (0.87–0.91) [0 FDR with CRC]	19.86 (7.29–43.24) [5+ FDR with CRC]
Scheuner, 201018	California Health Interview Survey 2005	33 187	mean 39.3 (18–64)	50% (weighted)	Incident CRC (OR)b	2.6 (1.2–5.7) [EITHER 1 FDR *or* 2 SDRs dx age <50 *or* 1 SDR dx age <50]	5.2 (1.7–15.8) [EITHER 1+ FDR dx age <50 *or* 2+ ADR *or* hereditary syndrome]
Murphy, 200924	Shanghai Women’s Health Study	73 358	median 50 (IQR 44–60)	100%	Incident CRC (HR)c	0.80 (0.20–3.29) [1+ sibling with CRC]	3.37 (1.59–7.12 [1 parent with CRC]
Leu 200825	Swedish Family Cancer Database	~7m	NR	NR	Incident CRC (RR)d	1.81 (1.57–2.08) [1+ parent dx age ≥60]	3.33 (2.14–4.53) [1+ parent dx age <60]
Kondo 200319	Japan Collaborative Cohort Study (JACC)	50 864	mean 57.7 ±10.1	58.5%	Incident CRC (OR)e	3.9 (1.7–8.4) [Second eldest]	6.3 (3.5–11.2) [Third eldest]
Poole 199922	Cancer Prevention Study (CPS)-1	429 483	mean 51	100%	CRC Mortality (OR)f	1.38 (0.67–2.83) [1+ FDR dx age ≥65]	4.89 (1.07–20.24) [1+ FDR dx <45]
Fuchs 19942	Nurses Health Study (NHS); Health Professionals Followup Study (HPFS)	119 116	Mean 49.1 (NHS); mean 51.5 (HPFS)	100% (NHS) 0% (HPFS)	Incident CRC (RR)g	1.64 (1.26–2.14) [1 FDR]	2.83 (1.33–6.02) [2+ FDR]
Nelson 199323	Iowa Women’s Health Study	40 657	Range 55–69	100%	Incident CRC (RR)h	-	1.29 (0.90, 1.85) [1+ mother/daughter]
Sandhu 200165	European Prospective Investigation into Cancer (EPIC)-Norfolk	30 353	Males: mean 59.4 Females: mean 58.9	55%	Prevalent CRC (age- adjusted)	1.38 (0.67–2.83) [1+ FDR dx age ≥65]	4.89 (1.07–20.24) [1+ FDR dx <45]

^fAbbreviations: FDR (first degree relative) SDR (second degree relative) ADR (any degree relative) CRC (colorectal cancer)