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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: Genet Med. 2015 Jan 15;17(9):702–712. doi: 10.1038/gim.2014.188

Table3.

Natural history: ADENOMA

Wark, 200926 Hoffmeister, 201027
Population HPFS: 1986–2004 33 GE clinics in Germany
% Female 0% 38%
Prevalence Odds Ratios Prevalence Prevalence Ratios
N Screened 0 FDR with CRC 23 880 2 929
1 FDR 3 445 -
1+ FDR 3 770 391
2+ FDR 325 -
N (%) with any
adenomaa 		0 FDR 2 378 (10.0) Refb,c 892 (30.5) Refb, c
1 FDR 532 (15.4) 1.75 (1.60–1.92) - -
1+ FDR 594 (15.8) 1.75 (1.60–1.91) 157 (40.2) 1.17 (0.95–1.44)
2+ FDR 62 (19.1) 2.36 (1.84–3.04) - -
  Women 0 FDR - 340 (23.1) Refb, c
1 FDR - 58 (30.7) 1.42 (1.02–1.97)
  Men 0 FDR - 552 (37.8) Refb, c
1 FDR - 99 (49.0) 1.42 (1.02–1.97)
N (%) with adv.
adenomad 		0 FDR 1 184 (5.0) Refb, e 319 (10.9) Refb, e
1 FDR 264 (7.7) 0.97 (0.80–1.17) - -
1+ FDR 297 (7.9) - 63 (16.1) 1.33 (1.00–1.76)
2+ FDR 33 (10.2) 1.08 (0.65–1.79) - -
  Women 0 FDR - 122 (8.3) Refb, e
1 FDR - 21 (11.1) 0.96 (0.55–1.67)
  Men 0 FDR - 197 (13.5) 1.46 (1.06–2.02)
1 FDR - 42 (20.8) 2.22 (1.47–3.33)
N (%) with 2+ distal
adenomas		 0 FDR 470 (1.9) Refb,f -
1 FDR 124 (3.4) 1.26 (1.02–1.63) -
1+ FDR 142 (3.6) - -
2+ FDR 18 (5.2) 1.76 (0.98–3.15) -
N (%) with 2+
proximal adenomas		 0 FDR 363 (1.5) -
1 FDR - -
1+ FDR 137 (3.5) -
2+ FDR - -
a

Wark: Non-advanced and advanced adenomas; Hoffmeister: Non-advanced and advanced adenomas and CRC

b

Wark: adjusted age, previous endoscopy, indication, aspirin, multivitamin, smoking, red meat, alcohol, folate, calcium, BMI, physical activity, total energy intake ; Hoffmeister: age at colonoscopy, gender, education, HRT use, BMI, physical activity, alcohol, red meat consumption

c

Wark: Odds ratio: adenoma vs. no adenoma within each family history level, Hoffmeister: Prevalence ratio between family history levels

d

Wark: Size ≥10mm *or* tubulo/villous structure *or* carcinoma in situ; Hoffmeister: Size ≥10mm *or* tubulo/villous structure *or* severe dysplasia *or* CRC

e

Wark: Odds ratio: advanced adenoma vs. non-advanced adenoma within each family history level, Hoffmeister: Prevalence ratio between family history levels

f

Wark: Rates of multiple vs. single adenoma