Table 2.
Panel reactive antibody data, stratified by mechanical circulatory support class. Mean± standard deviation is reported along with median (interquartile range).
| e | Non- missing Data |
No-MCS without history of cardiac surgery (n = 4533) |
No-MCS with history of previous cardiac surgery (n = 2699) |
P | All MCS (n = 3932) |
p | CF LVAD (n = 2532) |
p | PF LVAD (n = 811) |
p | BiVAD (n = 441) |
p | TAH (n = 121) |
p | RVAD (n = 27) |
P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Most recent panel- reactive antibody, class I |
11108 (93.8) |
5.0±15.3 0 (0–0) |
6.0±17.2 0 (0–1) |
0.007 |
9.2±21.1 0 (0–5) |
<0.001 |
8.8±20.4 0 (0–4) |
<0.001 |
9.0±21.1 0 (0–4) |
<0.001 |
10.4±22.1 0 (0–8) |
<0.001 |
17.6±29.1 2 (0–21.5) |
<0.001 | 4.6±12.6 0 (0–2) |
0.90 |
| Most recent panel- reactive antibody, class II |
10485 (88.6) |
4.4±15.2 0 (0–0) |
4.8±16.1 0 (0–0) |
0.28 |
5.4±16.6 0 (0–0) |
0.01 | 5.2±16.2 0 (0–0) |
0.04 | 4.2±14.7 0 (0–0) |
0.73 |
6.2±18.5 0 (0–0) |
0.02 |
13.0±25.2 0 (0–15.5) |
<0.001 | 3.4±10.5 0 (0–1) |
0.75 |
| Peak panel- reactive antibody, class I |
2720 (23.0) |
24.2±26.4 14 (5–34) |
29.9±29.6 19 (6–47) |
<0.00 1 |
34.4±31.1 24 (9–56) |
<0.001 |
33.3±30.6 23 (8–52) |
<0.001 |
38.3±32.7 28 (10–64) |
<0.001 |
34.6±30.9 24 (9–59) |
<0.001 |
39.3±32.3 30 (14–65) |
<0.001 | 10.0±12.4 6 (1–21) |
0.15 |
| Peak panel- reactive antibody, class II |
1542 (13.0) |
30.8±30.9 18.5 (3– 57) |
33.5±31.5 23 (6–60) |
0.21 | 34.1±31.1 25 (7–58) |
0.17 | 32.8±30.4 23 (7–56) |
0.32 | 37.3±32.8 30 (4–62) |
0.05 | 36.6±32.1 24 (10–58) |
0.14 | 43.1±35.6 27 (16–78) |
0.06 | 17.4±24.0 6 (4–17) |
0.33 |
| Composite most recent panel- reactive antibody, % |
11164 (94.3) |
7.38±18.8 0 (0–2) |
8.32±20.4 0 (0–3) |
0.046 |
9.1±20.9 0 (0–9) |
<0.001 |
11.2±22.6 0 (0–9) |
<0.001 |
10.4±22.7 0 (0–6) |
<0.001 |
13.0±25.1 0 (0–11) |
<0.001 |
21.4±31.3 4 (0–33) |
<0.001 | 5.7±12.7 0 (0–4) |
0.64 |
Abbreviations: MCS, mechanical circulatory support; LVAD, left ventricular assist device; BiVAD, biventricular assist device; TAH, total artificial heart; RVAD, right ventricular assist device.
*
P-value compares PRA levels against the baseline: patients without MCS and without prior cardiac surgery