Table 3.
Odds ratio of variables associated with patients with a durable mechanical circulatory support device at transplantation
| Demographics | P | |
| Age ≥60 y | 0.72 (0.65–0.80) | <0.001 |
| Male gender | 2.01 (1.79–2.26) | <0.001 |
| Race/Ethnicity | ||
| Caucasian | Reference | |
| African American | 1.10 (0.96–1.25) | 0.16 |
| Hispanic | 0.82 (0.69–0.98) | 0.03 |
| Other | 0.93 (0.73–1.19) | 0.57 |
| College education | 0.89 (0.81–0.99) | 0.03 |
| Private insurance | 1.00 (0.91–1.10) | 0.98 |
| BMI ≥35 kg/m2 | 1.83 (1.50–2.21) | <0.001 |
| Etiology of heart failure | ||
| Ischemic cardiomyopathy/CAD | Reference | |
| Idiopathic cardiomyopathy | 1.23 (1.10–1.37) | <0.001 |
| Graft dysfunction (retransplantation) | 0.15 (0.10–0.20) | <0.001 |
| Congenital heart disease | 0.24 (0.17–0.35) | <0.001 |
| Restrictive cardiomyopathy | 0.10 (0.06–0.15) | <0.001 |
| Hypertrophic cardiomyopathy | 0.34 (0.24–0.48) | <0.001 |
| Functional status, life support | ||
| NYHA class IV | 1.32 (1.19–1.45) | <0.001 |
| Inotrope support | 0.11 (0.10–0.12) | <0.001 |
| IABP support | 0.40 (0.31–0.51) | <0.001 |
| Ventilator support | 3.92 (2.90–5.31) | <0.001 |
| ECMO support | 1.66 (1.01–2.74) | 0.04 |
| Hemodynamic parameters | ||
| Mean pulmonary artery pressure ≥30 mmHg | 0.89 (0.81–0.98) | 0.02 |
| Renal/liver function, diabetes | ||
| CrCl< 50 mL/min or dialysis | 0.98 (0.86–1.12) | 0.77 |
| Diabetes | 1.12 (1.01–1.24) | 0.03 |
| Bilirubin ≥ 2mg/dL | 0.90 (0.78–1.03) | 0.13 |
| Panel-reactive antibody data | ||
| Composite most recent panel-reactive antibody ≥10% | 2.01 (1.79–2.27) | <0.001 |
| Transplant center characteristics | ||
| Year of transplant | 1.21 (1.18–1.24) | <0.001 |
| Moderate- or high-volume listing institution | 1.03 (0.94–1.13) | 0.56 |
| Operative characteristics | ||
| Bicaval anastomosis | 0.94 (0.85–1.04) | 0.22 |
| Organ ischemic time, ≥4h | 1.26 (1.13–1.40) | <0.001 |
| Donor characteristics | ||
| Age ≥50 y | 0.57 (0.47–0.68) | <0.001 |
| Smoking history >20 y | 1.09 (0.96–1.23) | 0.19 |
| Diabetes | 0.75 (0.58–0.98) | 0.03 |
| Donor/recipient matching | ||
| Gender match, n (%) | 1.15 (1.03–1.28) | 0.01 |
| Race match, n (%) | 1.01 (0.92–1.12) | 0.78 |
| CMV - donor positive, recipient negative | 0.99 (0.88–1.10) | 0.79 |
| Non-identical ABO blood group match (only compatible) | 0.81 (0.71–0.91) | 0.001 |
| Complete HLA mismatch (all 6 alleles) | 1.00 (0.89–1.12) | 0.98 |
Abbreviations: BMI, body mass index; CAD, coronary artery disease; NYHA, New York Heart Association; IABP, intra-aortic balloon pump; ECMO, extracorporeal membrane oxygenation; CrCl, creatinine clearance; CMV, cytomegalovirus; HLA, human leukocyte antigen.