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. 2016 Jul 20;29(8):309–315. doi: 10.1093/protein/gzw017

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Dimensional reduction of all H3N2 influenza sequences collected from humans in 2013 and 2014 and deposited in GenBank. Distances are normalized by the length of the HA1 sequence, 327 aa. Dimensional reduction identifies the principal observed substitutions, i.e. those correlated with fitness of the virus, which we expect to be in the epitope regions. A value of p_epitope = 0.19 corresponds to a distance of 0.012 here. Sequences from Table 2 are labeled. While the A/Texas/50/2012 sequence was collected in 2012, substantially similar strains were collected in 2013 and downloaded from GenBank.