Table 1.

Single Nucleotide Polymorphisms Included in the Present Polygenic Risk Score

SNP	Risk Allele	Gene	Gene-System Function	Phenotypes and Studies
rs686	G	DRD1	Dopamine	Cognitive Impulsivity (Oades et al., 2008); Nicotine Dependence (Huang et al., 2008); Alcohol Dependence (Batel et al., 2008); Smoking in Sx (Novak et al., 2010)
rs4648317	T	DRD2	Dopamine	Impulsivity (Hamidovic et al.,, 2009); Smoking and nicotine dependence (Laucht et al., 2008); Opiate addiction (Doehring et al., 2009)
rs1800497	T	ANKK1	Dopamine	Impulsivity (Chan et al., 2014), Reward dependence (Kazantseva, Gaysina, Malykh, & Khusnutdinova, 2011); Aggression (Zai et al., 2012); Opiate addiction (Doehring et al., 2009); Impulsivity, conduct problems (Esposito-Smythers, Spirito, Rizzo, McGeary, & Knopik, 2009); ADHD, low persistence (Nyman et al., 2007, 2012); ADHD (Gizer et al., 2009); Alcoholism (Munafo, Matheson, & Flint, 2007)
rs11575542	A	DDC	Dopamine/Serotonin	Sensation seeking (Derringer et al., 2010); Binge drinking (Pan et al., 2013); Drug dependence (Hack et al., 2011)
rs4570625	G	TPH2	Serotonin	Reduced prefrontal function during inhibition task (Baehne et al., 2008); ADHD (Walitza et al., 2005); Smoking (Reuter et al., 2007)
rs1455858	A	CHRM2	Cholinergic/Muscarinic	Impulsivity and Sensation seeking (Hendershot, Bryan, Ewing, Claus, & Hutchinson, 2011); Alcohol use disorder (Dick et al., 2007); Sensation/Novelty seeking (Dick et al., 2008)

Search terms: Impulsivity, Novelty seeking, Externalizing, Undercontrol, Delay Discounting, P300, Disinhibition, Stop Signal, Gambling Task, Sensation Seeking, Go-no-go, Risk Taking, Hyperactivity-Impulsivity, Conduct Disorder, Self-Regulation, Reward Seeking, Self-Control