Figure 2.

Impact of immunotherapy, targeted chemotherapy, and radiation therapy on tumors and the immune system as monotherapy and in combination. The top row depicts known impacts of immunotherapies through targeting checkpoint inhibitors, cytokine treatment, or adoptive cell therapy on tumor mass, and immune cell function in comparison to without treatment (top left). The left column depicts the known effects of other forms of therapy, such as targeted therapy, chemotherapy, and radiation therapy, on tumor mass and immune cell function in comparison to without treatment (top left). Intersections between forms of treatment represent the extrapolated effect on combining immunotherapies with other forms of therapy, based on known effects of regimens individually.