Table.
Association of Atrial Fibrillation Burden with Z-Scores of Selected Cognitive Tests, Atherosclerosis Risk in Communities Study, Visit 5 (2013–14)
| Model | AF burden, 1–6%, (paroxysmal) (n=14) | p | AF burden=100%, (persistent) (n=12) | p | |
|---|---|---|---|---|---|
| MMSE | M1 | −0.07 (−0.54 to 0.40) | 0.77 | −0.50 (−1.19 to 0.18) | 0.15 |
| M2 | −0.14 (−0.60 to 0.32) | 0.54 | −0.42 (−1.09 to 0.25) | 0.22 | |
| DWR | M1 | −0.17 (−0.50 to 0.15) | 0.30 | −0.62 (−1.21 to −0.04) | 0.04 |
| M2 | −0.17 (−0.54 to 0.20) | 0.37 | −0.44 (−1.05 to 0.16) | 0.15 | |
| ILdsp | M1 | −0.44 (−1.05 to 0.18) | 0.16 | 0.02 (−0.88 to 0.92) | 0.97 |
| M2 | −0.42 (−1.02 to 0.18) | 0.17 | −0.12 (−1.17 to 0.93) | 0.82 | |
| AN | M1 | −0.10 (−0.51 to 0.32) | 0.65 | −0.78 (−1.18 to −0.37) | <0.001 |
| M2 | −0.13 (−0.56 to 0.30) | 0.56 | −0.81 (−1.25 to −0.38) | <0.001 | |
| M3 | −0.13 (−0.55 to 0.29) | 0.55 | −0.75 (−1.17 to −0.34) | <0.001 | |
| M4 | −0.14 (−0.56 to 0.28) | 0.52 | −0.81 (−1.23 to −0.38) | <0.001 | |
| WF | M1 | 0.02 (−0.58 to 0.62) | 0.95 | −0.48 (−1.10 to 0.15) | 0.14 |
| M2 | −0.01 (−0.58 to 0.56) | 0.97 | −0.56 (−1.19 to 0.08) | 0.08 | |
| TMTa | M1 | 0.37 (−0.14 to 0.88) | 0.15 | −0.48 (−1.16 to 0.20) | 0.16 |
| M2 | 0.34 (−0.15 to 0.83) | 0.17 | −0.42 (−1.15 to 0.32) | 0.27 | |
| TMTb | M1 | 0.09 (−0.54 to 0.73) | 0.78 | −0.64 (−1.42 to 0.15) | 0.11 |
| M2 | −0.01 (−0.61 to 0.59) | 0.97 | −0.76 (−1.42 to −0.09) | 0.03 | |
| M3 | −0.04 (−0.64 to 0.56) | 0.90 | −0.70 (−1.32 to −0.07) | 0.03 | |
| M4 | −0.01 (−0.57 to 0.56) | 0.99 | −0.59 (−1.19 to 0.00) | 0.05 | |
| DSS | M1 | 0.02 (−1.16 to 0.28) | 0.94 | −0.44 (−1.16 to 0.28) | 0.24 |
| M2 | −0.07 (−0.52 to 0.38) | 0.77 | −0.41 (−1.04 to 0.23) | 0.21 | |
| DSB | M1 | 0.55 (0.001 to 1.10) | 0.05 | −0.75 (−1.46 to −0.05) | 0.04 |
| M2 | 0.57 (0.03 to 1.10) | 0.04 | −0.77 (−1.48 to −0.06) | 0.03 | |
| M3 | 0.57 (0.04 to 1.10) | 0.04 | −0.75 (−1.48 to −0.03) | 0.04 | |
| M4 | 0.57 (−0.04 to 1.10) | 0.04 | −0.75 (−1.48 to −0.02) | 0.04 |
Analyses were performed using general linear models. No AF (n=299) is the referent group.
M1: Adjusted for age and sex; M2: M1 + educational level, smoking status, body mass index, hypertension, diabetes, coronary heart disease, heart failure, warfarin use, and left ventricular ejection fraction; M3: M2 + prevalent clinical stroke; M4: M3 + presence of subclinical cerebral infarcts
AF=atrial fibrillation; MMSE=mini-mental state examination
Memory: DWR=Delayed Word Recall Test; ILdsp=Incidental Learning, digit-symbol pairs, part B
Verbal fluency: AN=Animal Naming; WF=Word Fluency
Executive function: TMT=Trail Making Test; DSS=Digit Symbol Substitution; DSB=Digit Span Backwards