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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: Brain Behav Immun. 2015 Jul 26;50:249–258. doi: 10.1016/j.bbi.2015.07.022

Fig. 4.

Fig. 4

Altered cortical excitatory and inhibitory synaptic transmission in the MIA offspring. (a) mEPSCs recorded from layer 2 pyramidal neurons in somatosensory cortex from control and MIA offspring. (b) Reduced mEPSCs frequency (control (black): 1.22 ± 0.05 Hz, n = 9 mice, 28 cells; MIA (red): 0.90 ± 0.1 Hz, n = 8 mice, 32 cells, P = 0.007) with no difference in the amplitude of mEPSC (control: 15.72 ± 0.44 pA, MIA: 16.91 ± 0.51 pA, P = 0.097) was observed in the MIA offspring. (c) mIPSCs recorded from layer 2 pyramidal neurons in somatosensory cortex from control and MIA offspring. (d) No difference in mIPSCs frequency (control: 3.82 ± 0.26 Hz, n = 12 mice, 41 cells; MIA: 3.33 ± 0.29 Hz, n = 9 mice, 35 cells, P = 0.226) and increased mIPSC amplitude (control: 36.51 ± 1.82 pA, MIA: 42.25 ± 1.93 pA, P = 0.046) was observed in MIA offspring. Data are represented as mean ± SEM. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)