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. 2016 Jun 17;12:1744806916648153. doi: 10.1177/1744806916648153

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — DA mediates inhibition by D2. Inhibition of D2Rs by sulpiride blocked the inhibitory effects of DA. (a) Sample trace of a neuron recorded with sulpiride (30 μM) applied 5 min after baseline and DA (50 μM), 10 minu after the baseline. (b) Averaged and normalized (%) eEPSCs recorded in presence of sulpiride (30 μM) and DA (n = 7/5 mice). (c) Sample eEPSC trace for sulpiride (100 μM) and DA. (d) Averaged data (%) showing no inhibition by DA in presence of sulpiride (100 μM; n = 6/4 mice). (e) Statistical analysis of mean eEPSCs for DA alone and DA in presence of both concentrations of sulpiride. Combination of sulpiride (30 μM) and DA significantly lowered eEPSC amplitude (***P < 0.001) and sulpiride (100 μM) + DA did not have significant influence on the baseline transmission (t-test, P = 0.649). Error bars represent SEM. eEPSCs: evoked excitatory postsynaptic currents; DA: Dopamine.