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. 2016 May 10;65(8):2187–2200. doi: 10.2337/db16-0213

Figure 1.

Figure 1

Fatty liver disease in 12-week-old lipodystrophic mice. Blood glucose (A), liver weight (B), and liver triglycerides (TG) (C) in 12-week-old, random-fed control, F-IGFRKO, F-IRKO, and F-IR/IGFRKO mice. Results are mean ± SEM of 12 to 30 animals per group. D: Liver sections from the same mice stained with H&E. mRNA expression of genes involved in de novo lipogenesis (E), inflammation (F), and fibrosis (G) in the livers of 12-week-old control, F-IGFRKO, and F-IRKO mice. H: Liver sections from control and F-IR/IGFRKO mice stained with DHE and 4-HNE. I: Expression of gluconeogenic/glycolytic enzymes in the livers of chow-fed control, F-IGFRKO, F-IRKO, and F-IR/IGFRKO mice at 12 weeks of age. Results are mean ± SEM of five to seven animals per group. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.