Skeletal muscle microvascular perfusion and eicosanoids in rhesus macaques in response to fluconazole. Microvascular blood flow (A) and CBV (B). *P < 0.01 vs. rest CBV; †P = 0.03 vs. day 1 peak CBV. C: Average 12- and 15-HETE eicosanoid vasodilators. ‡P < 0.05 for pre- vs. postfluconazole values on day 2. D: Average 18-, 19-, and 20-HETE eicosanoid vasoconstrictors. §P < 0.01 for pre- vs. postfluconazole values on day 2. E: Average eicosanoid vasodilators (8,9-, 11,12-, and 14,15-EETs and corresponding DHETs).