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. 2016 May 10;65(8):2380–2391. doi: 10.2337/db16-0154

Figure 3.

Figure 3

TRIB3 MKO mice were protected from high-glucose–induced insulin resistance in diabetes. A: Induction of hyperglycemia in control and TRIB3 MKO 20-week-old male mice (n = 8–12) by intraperitoneal injection of STZ (50 mg/kg BW for 5 consecutive days). B: Similar weight loss between control and TRIB3 MKO mice during hyperglycemia. C: ITTs (Humalog, 0.3 units/kg BW) were done at the very initial beginning of hyperglycemia (day 7), showing similar insulin sensitivity between groups. D: ITT (Humalog, 0.3 units/kg BW ) repeated after 4 weeks of hyperglycemia in TRIB3 MKO mice and control mice. E and F: Western blot analysis of total protein O-GlcN acylation in skeletal muscle of TRIB3 MKO and TRIB3 MOE diabetic mice. Data are means ± SEM. *P < 0.05 and **P < 0.01 vs. control group by the Student t test and two-way ANOVA.