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. 2016 May 10;65(8):2380–2391. doi: 10.2337/db16-0154

Figure 6.

Figure 6

HFD feeding induced insulin resistance in TRIB3 MKO mice. A: Similar BW gain in control and TRIB3 MKO mice fed with the HFD for 16 weeks (n = 7–12). B. Compared with control mice, TRIB3 MKO mice had a significantly lower level of fasting blood glucose after being fed the HFD. C: Expression of gluconeogenic gene PEPCK in TRIB3 MKO and control mice under fasting. D: ITT (Humalog, 0.5 units/kg BW, i.p.) showed improved insulin sensitivity in TRIB3 MKO mice compared with control mice (n = 7). E: Western blot analysis of insulin signaling proteins in muscle tissue collected after 30 min of insulin injection (0.5 units/kg BW, i.p.), which showed increased p-GSK3 α/β and p-AKT (308) in skeletal muscle of TRIB3 MKO mice. Data are means ± SEM. *P < 0.05 and **P < 0.01 vs. control group by two-way ANOVA.