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. 2016 Jul 15;9:29–45. doi: 10.2147/NSA.S99747

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© 2016 Wingett et al. This work is published and licensed by Dove Medical Press Limited

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Dissolution of ZnO NPs in intracellular and extracellular environments.

Notes: (A) The intracellular zinc concentration occurring from NP dissolution inside the cell was determined by treating Jurkat cells with either −30, −9, and +44 mV ZnO NPs (0.15 mM) for 8 hours and intracellular zinc concentration determined by ICP-MS (n=3, means ± standard error). (B) The extracellular dissolution of NPs was determined after 24-hour incubation of ZnO NPs in PBS using ICP-MS (n=3, means ± standard error). Results were analyzed using one-way ANOVA and model-based means test. Asterisks denote statistical significance (P<0.05).

Abbreviations: NP, nanoparticle; ICP-MS, inductively coupled plasma mass spectrometry; PBS, phosphate-buffered saline; ANOVA, analysis of variance; NT, no treatment.