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. 2016 Jul 21;11(7):e0159211. doi: 10.1371/journal.pone.0159211

Fig 6. Time-dependent antiviral effects of HCV IRES-specific siRNAs on patient-derived HCV genotype 4 isolates.

Fig 6

Huh-7 cells infected with patient-derived genotype 4 isolates, transfected with HCV353, HCV258, and negative control siRNAs were harvested at the indicated time points (24, 48, 72 h post-transfection) and HCV genomes determined using qRT-PCR analysis. Black and white columns indicate HCV-specific siRNA and negative control siRNAs, respectively. X-axes and y-axes depict the time post-transfection and HCV genomes, respectively. (A) HCV353 and (B) HCV258 siRNA inhibition of HCV genotype 4. Data are presented as the mean ± SEM values of two wells measured in triplicate.