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. 2016 Mar 8;12:1744806916629049. doi: 10.1177/1744806916629049

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Blocking TRPV1 positive C-fibers does not reverse mechanical hypersensitivity induced by thalamic collagenase injection. (a) Timeline of thalamic collagenase injection and intraplantar QX-314/capsaicin injection. (b) Injection of QX-314/capsaicin significantly increases mechanical threshold in saline-injection mice but fails to do so in collagenase-injected animals (^tP < 0.05 as compared to basal; *P < 0.05 as compared to corresponding control mice; repeated measures ANOVA, post-hoc Fisher’s test; n = 6–8).