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. 2016 Jul 5;12:1744806916660722. doi: 10.1177/1744806916660722

Figure 2.

Figure 2.

SAHA prevents/attenuates stress-induced visceral hypersensitivity and increases histone acetylation in the LS spinal cord. (a) The magnitude of VMR one-day post FS following SAHA or DMSO pretreatment. Data were normalized to each rat’s baseline response. #p < 0.01 vs. DMSO + FS group; *p < 0.001 vs. baseline; n = 16 for SAHA + FS group and n = 19 for DMSO + FS group. (b) The magnitude of the VMR one day following three daily injections of SAHA in the absence of FS (n = 18). Data were pooled from all animals administered SAHA in the absence of stress. (c, d) The magnitude of the VMR following one or three daily injections of SAHA or DMSO starting one day after the last FS. *p < 0.05 vs. baseline (B), #p < 0.05 vs. three-day post FS. n = 13 for FS + SAHA group, n = 8 for FS + DMSO group. (e) FS had no effect on histone acetylation. (f) SAHA prior to FS increased H3K9Ac compared with vehicle. *p < 0.05, n = 5–7 per group for Western blots.