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. 2016 May 12;12:1744806916646784. doi: 10.1177/1744806916646784

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — The activation of microglia in the spinal dorsal horn or CNS regions is interfered by the change of peripheral IL-1β signaling. (a–c) Representative pictures showing that microglia were activated in different regions of the CNS at 12 days following SNI (a) and was blocked by peri-sciatic application of IL-1β neutralizing antibody (b) (n = 3/group). Iba1 is a microglial marker. (c) Tail-intravenous injection of rrIL-1β but not vehicle induced the activation of microglia. (n = 3–4/group). (d) Bar graph summarizing the number of Iba1 positive cells area in various regions of the CNS in different treatment groups. *P < .05; **P < .01; ***P < .001 vs. sham group. ^##P < .01; ^###P < .001 vs. IgG + SNI group. SDH: spinal dorsal horn; NAcc: nucleus accumbens; AMG: amygdala.