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. 2016 Jul 21;11(7):e0159899. doi: 10.1371/journal.pone.0159899

Fig 1. KLF12 promotes tumor growth in vitro and in vivo.

Fig 1

(A) KLF12 protein levels in CRC cell lines. Actin served as a loading control. (B) KLF12 expression (top) and cell viability (bottom) of LS174T cells stably transfected with either GFP or KLF12. Actin served as a loading control. C. KLF12 expression (top) and cell viability (bottom) of HCT116 cells stably transfected with either a vector containing nonsilencing control shRNA (shCon) or one of two KLF12 shRNAs (shKLF12-1 and shKLF12-2). Actin served as a loading control. D. Tumor weight in mice orthotopically injected with either LS174T/GFP or LS174T/KLF12 cells (n = 8 for each group). E. Tumor weight in mice orthotopically injected with either HCT116/shCon, HCT116/shKLF12-1, or HCT116/shKLF12-2 cells (n = 9 for each group).