Table 2.
Statistical summary: Impact of capsaicin and genotype (FAAH KO vs. WT) on levels of arachidonic acid derivatives in paw skin and lumbar spinal cord.
| Compound | Tissue | Capsaicin (vs. vehicle) | Genotype (vs. WT) | Interaction | Figure |
|---|---|---|---|---|---|
| 2-AG | Paw skin | NS | NS | NS | 11(a) |
| Spinal cord | F1,20 = 7.897, p < 0.05 ↓ | NS | NS | 11(b) | |
| AA | Paw skin | F1,20 = 45.56, p < 0.0001 ↑ | NS | NS | 11(c) |
| Spinal cord | F1,20 = 7.897, p < 0.05 ↑ | NS | NS | 11(d) | |
| PGE2 | Paw skin | F1,20 = 7.837, p < 0.05 ↑ | NS | NS | 11(e) |
| Spinal cord | F1,20 = 6.488, p < 0.05 ↑ | NS | NS | 11(f) | |
| PGF2α | Paw skin | F1,20 = 4.943, p < 0.05 ↑ | NS | F1,20 = 4.762, p < 0.05 | 11(g) |
| Spinal cord | NS | NS | NS | 11(h) |
2-AG: 2-arachidonoyl-sn-glycerol; AA: arachidonic acid; NS: not significant; ↑: increase, ↓: decrease.