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. 2016 May 4;12:1744806916646379. doi: 10.1177/1744806916646379

Figure 1.

Figure 1.

Paw withdrawal thresholds to mechanical stimulation. Bar graphs show the results of the von-Frey test in naïve 2, 6–9, 12–15, and ≥18 months old α-GAL deficient (Fabry ko) and wild-type (WT) male (a) and female (b) mice. Male and female Fabry ko mice show reduced mechanical withdrawal thresholds when compared with their WT littermates starting at the age of two months and lasting up to ≥18 months of age. In (c) results of male and female naïve 2 and ≥18 months old α-GAL deficient Fabry ko and WT mice are averaged each. Young and old Fabry ko mice show reduced mechanical withdrawal thresholds when compared with their WT littermates. Fabry ko: 2 months (9 male, 17 female), 6–9 months (29 male, 44 female), 12–15 months (22 male, 10 female), ≥18 months (29 male, 55 female). WT: 2 months (6 male, 6 female), 6–9 months (13 male, 8 female), 12–15 months (36 male, 16 female), ≥18 months (25 male, 16 female). F = female; M = male; mo = months; *p < 0.05, ***p < 0.001.