Figure 8.

Weight change in a one-week treadmill experiment. Bar graphs show the weight change during the one-week treadmill experiment in α-GAL deficient (Fabry ko) and wild-type (WT) male (a) and female (b) mice. Male Fabry ko mice lost more weight in the treadmill than their WT littermates, while weight loss in female mice was not different between genotypes except for old female Fabry ko mice compared to their WT littermates. Fabry ko: 2 months (13 male, 18 female), 6–9 months (45 male, 29 female), 12–15 months (31 male, 18 female), ≥18 months (46 male, 48 female). WT: 2 months (10 male, 10 female), 6–9 months (46 male, 22 female), 12–15 months (36 male, 21 female), ≥18 months (29 male, 11 female). F = female; M = male; mo = months; *p < 0.05, **p < 0.01, ***p < 0.001.