. 2016 Jul 21;12(7):e1005725. doi: 10.1371/journal.ppat.1005725

Table 1. The origins, drug susceptibilities, and PfCRT haplotypes of different 106/1 and K1 P. falciparum lines.

Line or isolate ^a	Origin or drug selection	PfCRT variant	Drug susceptibility ^b (In vitro resistance index)			Amino acid changes in PfCRT ^c
Line or isolate ^a	Origin or drug selection	PfCRT variant	CQ	QN	QD	72	74	75	76	163	220	271	326	352	369	356	371
HON	Africa	PfCRT^3D7	1	1	1	C	M	N	K	S	A	Q	N	Q	V	I	R
Dd2	Indochina/Laos	PfCRT^Dd2	11.78 ± 0.18	1.82 ± 0.31	2.88 ± 0.46	C	I	E	T	S	S	E	S	Q	V	T	I
106/1	Sudan	76K-PfCRT^K1	1.10 ± 0.06	1.08 ± 0.06	1.01 ± 0.01	C	I	E	K	S	S	E	S	Q	V	I	I
106/1^76T	CQ	PfCRT^K1	12.95 ± 0.95	1.69 ± 0.19	1.95 ± 0.05	C	I	E	T	S	S	E	S	Q	V	I	I
106/1^76N	CQ	76N-PfCRT^K1	8.60 ± 0.90	1.56 ± 0.16	1.08 ± 0.08	C	I	E	N	S	S	E	S	Q	V	I	I
106/1^76I	CQ	76I-PfCRT^K1	15.66 ± 2.20	0.11 ± 0.04	1.72 ± 0.13	C	I	E	I	S	S	E	S	Q	V	I	I
106/1^72R,76I	CQ then QN	72R,76I-PfCRT^K1	1.13 ± 0.07	0.76 ± 0.07	0.87 ± 0.06	R	I	E	I	S	S	E	S	Q	V	I	I
106/1^76I,352K	CQ then QN	76I,352K-PfCRT^K1	0.91 ± 0.09	0.93 ± 0.25	1.28 ± 0.07	C	I	E	I	S	S	E	S	K	V	I	I
106/1^76I,352R	CQ then QN	76I,352R-PfCRT^K1	1.58 ± 0.02	0.99 ± 0.16	0.88 ± 0.02	C	I	E	I	S	S	E	S	R	V	I	I
106/1^76I,369F	CQ then AMT ^d	76I,369F-PfCRT^K1	3.53	0.28	0.98	C	I	E	I	S	S	E	S	Q	F	I	I
K1AM	CQ then AMT	163R,356V-PfCRT^K1	0.95	0.72	n.d.	C	I	E	T	R	S	E	S	Q	V	V	I

^aThe 106/1-derived lines were generated by Cooper and colleagues [11, 12, 14] and the K1AM line was produced by Johnson et al. [15].

^bThe susceptibilities of the parasite lines to CQ, quinine (QN), and quinidine (QD) were collated from Cooper et al. [11, 12, 14] and Johnson et al. [15]. The drug resistance index is the IC₅₀ for a drug in a given strain or line divided by the IC₅₀ determined in the same study in a drug-sensitive reference strain (i.e., 106/1, HON, or GC03). The indices were calculated from a single study or are the mean of values from two (± range/2) or ≥ three (± SEM) studies.

^cResidues that differ from the wild-type amino acid sequence (e.g., the PfCRT sequence carried by 3D7, D10, and HON parasites) are shown in bold italics.

^dCQ-resistant parasites are hypersensitive to amantadine [13, 15].