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. 2016 Jul 21;11(7):e0159850. doi: 10.1371/journal.pone.0159850

Fig 6. The N-IF mouse phenotype is dominant and dependent on a NOD gene(s).

Fig 6

(A) H&E stained liver section from a 10 weeks old F1(24αβNOD Rag2-/- x B6.Rag2-/-) mouse, with an inserted magnified image of the portal tract. Representative image from two independent experiments with a total of six mice is shown. The size bar is 100 μm. (B) Liver weight of 9–21 weeks old N-IF, F1(24αβNOD.Rag2-/- x B6.Rag2-/-) and backcrossed 24αβB6.Rag2-/- mice (n = 4–5). (C) Liver weight of 8–12 weeks old N-IF mice, single transgenic TCRα and TCRβ mice expressed in NOD.Rag2-/- mice and 24αβNOD mice (n = 3–6). Data in B and C are from one experiment representative of two independent experiments and shown as mean ± SEM. Statistical analysis was performed using unpaired t-test where ***p<0.001.