Fig 6. Comparison of epitope-specific binding Abs in rabbit immune sera following immunization with monomeric or dimeric TV1.C and 1086.C gp120s.

V3-specific reactivity was used as a control and, as expected, showed similar binding to monomeric and dimeric gp120s. Monomeric gp120 elicited higher titers of conformational Abs directed against V1V2 and CD4BS epitopes (Ns = not significant; * = p<0.01; ** = p<0.001).