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. 2014 Oct 31;7(3):1125. doi: 10.4022/jafib.1125

Table 1. Summary of studies evaluating non-inducibility as an endpoint of atrial fibrillation ablation.

Author Year N AF Type Induction protocol Definition of inducibility Follow-up Results
Haissaguerre et al. 2004 70 AF with episode ≥ 1 hour Decremental burst pacing (5 sec) AF ≥ 1 min 7±3 months 87% of non-inducible patients vs. 62% of inducible patients (P=0.03) were AF-free
Oral et al. 2004 100 Paroxysmal AF Rapid atrial pacing (≥ 15 sec @ shortest cycle length with 1:1 atrial capture) AF > 1 min 6 months 85% of non-inducible patients after PVI vs. 67% of inducible patients after PVI vs. 86% patients who received further ablation after PVI when inducible were AF-free
Essebag et al. 2005 102 Paroxysmal and persistent AF Burst pacing (5 sec @ 200 ms) ± isoproterenol AF or left atrial tachycardia > 10 sec 1 year 72% of non-inducible patients vs. 53% of inducible patients (P=0.04) were AF-free
Jais et al. 2006 74 Paroxysmal AF Decremental burst pacing (10 sec) AF ≥ 10 min 18±4 months 91% of non-inducible patients were AF-free.
Richter et al. 2006 234 Paroxysmal (n=165) and persistent (n=69) AF Decremental burst pacing AF > 1 min 6 months Non-inducibility had 46.7% sensitivity and 75% specificity for AF recurrence
Chang et al. 2007 88 Paroxysmal AF Decremental burst pacing (5-10 sec) AF or atrial flutter > 1 min 12±6 months 81% of non-inducible patients after PVI vs 84% of non-inducible patients after PVI plus additional ablation vs 45% of paitnets inducible after PVI plus additional ablation were AF-free
Crawford et al. 2010 112 Paroxysmal AF Decremental burst pacing (5-10 sec)Isoproterenol (up to 20 µg/min) AF up to 15 mins after infusion 12±5 months 84% of patients non-inducible with isoproterenol (33% sens, 97% spec), vs 76% of patients non-inducible by pacing (44% sens, 72% spec) were AF free
Decremental burst pacing (10 sec) AF ≥ 1 min
Satomi et al. 2008 60 Paroxysmal AF Decremental burst pacing (10 sec) AF > 10 mins 16±8 months 58% of non-inducible patients vs 59% of inducible patients were AF free
Leong-Sit et al. 2013 144 Paroxysmal (n=78) and persistent (n=66) AF Decremental burst pacing (15 beats) AF or atrial tachycardia/flutter ≥ 2 mins 1 year 51% of non-inducible patients vs 51% of inducible patients were AF free