Table 3. Studies comparing conventional biventricular pacing with multisite pacing through a quadripolar lead.

NYHA, New York Heart Association functional class

First author, year	n	Comparison	Study findings
Thibault, 2013 (88)	19	Distal electrode versus 4 multisite pacing configurations	Invasive dP/dt better with multisite pacing in 72% (mostly through combined proximal and distal electrode stimulation)
Rinaldi, 2013 (89, 91)	41/40	Distal electrode versus 8 multisite pacing configurations	1. Dyssynchrony by tissue Doppler echocardiography reduced in 63% with multisite pacing 2. Radial strain >20% higher in 63% with multisite pacing
Pappone, 2014 (90)	44	Distal/proximal electrode versus 7 multisite pacing configurations	Acute improvement in hemodynamic parameters and significant decrease in NYHA with more pronounced reverse remodeling after 3 months in multisite pacing group