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. 2016 May 20;12:1744806916649191. doi: 10.1177/1744806916649191

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — CB1R expression affects the development of cold and mechanical hypersensitivity following SNI in mice. (a) Cold responses in ipsilateral paws of CB1R−/− mice are significantly higher than CB1R+/+ responses (*p < 0.05; **p < 0.01; ***p < 0.001) and CB1R−/− mice develop this phenotype at day 7 (^p < 0.05 vs. CB1R+/+). Two-way ANOVA with Tukey’s post hoc test with multiple comparisons. (b) Cold responses in the contralateral paws, *p < 0.05, **p < 0.01 CB1R−/− vs. CB1R +/+; #p < 0.05 CB1R−/− vs. CB1R+/−. Significances between ipsilateral and contralateral paws are indicated in results. (c) Percentage change in mechanical thresholds calculated from baseline before surgery (POD -3). All genotypes develop mechanical hypersensitivity, but beginning at POD14 up to POD28, thresholds are significantly higher in the knockouts (CB1R−/− and CB1R+/−) compared to CB1R+/+. ^p < 0.05; @ p < 0.01; $ p < 0.001; #p < 0.0001 vs. baseline; *p < 0.05; ***p < 0.001 versus CB1R+/+ at particular time point. (d) Percentage change of contralateral paw mechanical thresholds.