Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic overview. When nerve injury occurs, IFNγ levels are increased in the dorsal horn of the spinal cord and binds to IFNγ receptors on microglia. CCL2 subsequently enhances the neuronal NMDA-induced inward current in lamina II neurons via CCR2. This potentiation of NMDA receptors likely contributes to the development of neuropathic pain. CCL2: chemokine ligand 2; CCR2: C-C chemokine receptor type 2; IFNγ: interferon-gamma; SG: substantia gelatinosa.
